Should it count as a meme? So far I’ve found some info that it originally came from a badly translated Indian pr0nz website called Sayitabhabbi.com, which is now defunct, and it seems to have become popular around May 2011, with a lot of activity still going on around Tumblr.
Got this posted on my wall recently:
If there are more examples I can say it’s got potential.
I would say yes, the last panel is commonly used as a reaction image.