Anyone who's played No More Heroes probably gets it, but just to fill those unfortunate enough to have not, the main character Travis Touchdown calls the character Henry this in the sixth level during a cutscene, link provided below:
https://www.youtube.com/watch?v=MkCpSuzWO0A
Anywho, it hasn't gained real notoriety quite yet, but it's a pretty common quote among fans and was used in various articles (i.e Kotaku) when Henry was announced a a playable character in the second game. Past that, there have also been a few videos around YouTube about it, including this parody of the Six Flag commercials with the old man:
https://www.youtube.com/watch?v=TdMDdwlnfzg
So I raise the question: Does this have meme potential?