WELLLLL HE AIN'T MY BOY BUT THE BROTHER IS HEAVY
This meme started in 2006 with the release of the videogame "Dead Rising," which tells the story of a photojournalist named Frank West who went to the fictional town of Willamette, Colorado to investigate why the military has quarantined the town. He gets stuck inside Willamette Parkview Mall with zombies and a small group of survivors because he hired a helicopter to enter the town and pick him up in three days.
In this game, Frank encounters a group of escaped convicts who have stolen a military Humvee and attack anyone they see in a sort of perverted game. Whenever they are present, the game plays their theme song, "Gone Guru" by Lifeseeker.
Amongst players of the game, this song is both loved and dreaded. It's easily the catchiest song in the game, but at early levels of the game, before Frank earns more abilities and health, the convicts can make mincemeat out of Frank with the Humvee's heavy machinegun or simply by running him over.
Full song (lyrics in the description): https://www.youtube.com/watch?v=PUpoMzB-5w4
Origin: https://www.youtube.com/watch?v=--MKH6G-Ab0