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Learn/Know The Difference, It Could Save Your Life is an expression used in images to show the difference between two things, in a manner not too different from The Main Difference Between Europe and USA.
The earliest known example of such image can be dated back to October 9th, 2006, when an image macro depicting the difference between Mormons and Ninjas was uploaded on the site MyConfinedSpace by a user tiki god.
On December 8th, 2006, a user of EVE Search forums Ma Raia’l published a post explaining the difference between the Barrel Roll and the Aileron Roll, also containing a link to the image macro not too different from the one with Ninjas and Mormons. On November 5th, 2011, the image was posted at WeKnowMemes, and on November 7th, the same year, it was used in a comment at AnandTech Forums.
On July 28th, 2007, in a thread on 4chan’s /b/ (random) board, an image showing the difference between 4chan and another site Something Awful, along with a comment “learn the difference” was uploaded.
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