Sickos Haha Yes refers to a reaction image taken from a Stan Kelly comic drawn for The Onion. It depicts a man in a shirt labeled "Sickos" looking in on a scene from a window while saying "Yes… Hahaha… Yes!" The frame is typically paired with news or images others might be turned off by but the poster is excited about.
The frame comes from Kelly's comic "Painful Procedural," which was posted on February 16th, 2015. The comic depicts a world where all drugs are legalized, leaving TV detectives with no crimes to solve. While a family watches the show with horror, a man labeled "Sickos" looks on from the window saying "Yes… hahaha… yes!" (shown below).
The comic appeared in a 4chan thread celebrating Kelly's work on October 23rd, 2016. On December 9th, 2017, the isolated "Sickos" man was uploaded to ShitpostBot 5000 (shown below). This frame is often used as a reaction image on Twitter to posts expressing perverse enjoyment about something.
The frame grew into a reaction image in the late 2010s and through 2020. It has been used to express excitement about events others might find distasteful or unwanted. Recent examples include a July 21st, 2020 post by Redditor alfredosolisfuentes on /r/twinpeaks using it to reference season 2 episodes of Twin Peaks (shown below, left) and a Novermber 6th post by Twitter user @dellcam in reference to protestors outside an Arizona polling place during the 2020 United States Presidential Election (shown below, right).