Pinkie's sick
Fluttershy is a Drunk B***h
Applejack seems to still be sober although she may also be drunk.
Rainbow Dash is most likely Drunk and saying "I love you mane or filly or whatever"
Rarity drinks wine with class, and doesn't look drunk, just wet?
Twilight went off the deep end, she's past hung over.

The last supper.