New Series Weekdays on Cartoon Network! They Mayor must defeat Bianca and Barbarus in order to save the Powerpuff Girls! Blossom, Bubbles and Buttercup, the original arbiters of girl power, are back on Cartoon Network! The Powerpuff Girls, the beloved global phenomenon, will return this spring with a brand-new, re-imagined series about three girls juggling school and saving the world before bedtime.