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This meme orginated from the Strong Bad E-Mail Video Game
Title is deliberate Engrish from the Strong Bad Email “video games” and subsequent game “StrongBadZone” on Homestar Runner, wherein the head of the person playing the game is presumed not to have actually exploded, although there have been no studies done on the matter so far as we are aware. – Television Tropes & Idioms
There are many videos on youtube with Your Head Asplode in the title to describe someone’s head exploding in the clip, or a clip that will result in Your Head Asploding. You can also purchase head asplode t-shirts on CafePress.ca.
Most Google search results are photo descriptions, blog titles or forum posts that contain the phrase “head asplode”.