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Know Your Meme is a website dedicated to documenting Internet phenomena: viral videos, image macros, catchphrases, web celebs and more.
CSI 4-Pane Comics
Anything that Lieutenant Horatio Caine (CSI: Miami) says sounds profound when he's putting on his sunglasses. …On top of his sunglasses.
'60s Spider-Man
Absurd text + old Spider-Man cartoon images = hilarious.
Assuming Control
If you've ever played Mass Effe-- ASSUMING DIRECT CONTROL.
Are You Serious Face
This popular rage comic face comes from the same video clip that started the image macro series Bill O'Reilly / You Can't Explain That.
Pic Unrelated
Does anyone know how to beat level 42 in Angry Birds?