Metroid - They must have never finished Metroid 86

Obligatory:

Did you crawl out from under of a rock?
Has anyone welcomed you to the internet, do you need a tour?
I kid.

Yes, it's that famous and popular. There's even a page here on kym on the soon (god I hope) to be released Metroid Prime 4 wrote 4 years ago. In addition Samus is the go-to badass woman besides Lara croft that most gamers think of when the term stonk female protag is mentioned.
It even has an entire sub-genre half-named after it
https://en.wikipedia.org/wiki/Metroidvania