An early rage comic adaptation of a common English interjection, the "Mother of God" reaction face is typically used as an affirmation of WIN or FAIL, depending on the context.

In the latest issue of scientific journal Nature Biotechnology, Harvard and California Institute of Technology professors unveiled their creation of an artificial jellyfish made from the heart muscle cells of a rat. So this is what science has done. …Where is your god now?

80s & 90s Nostalgia: This remix track created by musician DarkMateria remained relatively obscure until it was featured on a YTMND page in April of 2004.

In this latest episode of Conan O'Brien's new game review series Clueless, the late night talk show host tries out Minecraft and makes fun of its minimalist graphics and "depressing climates."

…Dear Mother of Nicolas Cage.