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TMP-SMX mechanisms of resistance Reducedaug accumulation.via reduced membrane permeability and increased efflux.activity brug modufication/inactivation by enzymes 'Iarget site modification via mutatlons Fo DHPS, gene duplicatlans, or a plasmid with mutations in the TMP or SMX binding sites OVERVIEW OF ANTIBIOTICS •B-lactams: inhibut cell wall synthesis; bactencidal >Denicillins, cephalosporuns. Sulfonamides: prevent growth.and replication; bacteriostatic Prontosu, sulfadiazıne, suifisoxazole Aminoglycosides: inhibit protein synthesis; bactenadal Sreptomycin, neomycin, kanamyan, paro momycin ·Tetracycine : inhibit protein synthesis; bactenostatic →Tetracycline, doxyaycline, limecycine, oxytetracycine • Chicramphenicol: innioits protein synthesis; bactenostatic • Macrolides: inhibit protein synthesis; bacterostatic Erythromyciny. clanthromycin, azuthromycin. • Glycopeptides: inhubit ceul wau synthesis; bactericidal → Vancomycin, teicoplanin Ansamycins: innibit RNA synthesis; bacteriadal → Geldanamy un, nfamycin, naphthonycin al • Quinolanes: interfere with DNA replication and transcrptom, m →uprofloxaciny levofloxacin, trovafloxacin Streptogramins: inhubut protein synthesis; bactena" •Oxazolidinenes: inhibit protein synthesis; bact →Linezolid, pOszolid, tedizolid, cycoserir functions; bactenadal ·Lupopeptides:disrupt muetple cell me. Daptomyin sUi fou

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LAUNDRY TOKEN USAGE For use in Washer/Dryer For use in Vending Machine CHUCKE ROCKS PRINCESS Snuggle Liquid

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TO MY MASTER, LHAVE TO TELL YOU *I AM NUDE11 *i HAVE NO PROTECTIVE COATING ON TENDER SKIN *! AM AFRAID OF RAIN AND DIRT, AS NUDE NATUIRE CAUSES ME TO SPOT BUT *! WILL PROMISE TO GIVE YOU MVO COMFORT AND PLEASURE IF YOU TA GOOD CARE OF ME AND TREAT ME PRECIOUSLY AND DELICATELY! PROFESSIONAL CLEANERS ONLY OUTER SHELL LEATH LINING : 100% RAYO! MADE IN HONG KON

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TMP-SMX mechanisms of resistance Reducedaug accumulation.via reduced membrane permeability and increased efflux.activity brug modufication/inactivation by enzymes 'Iarget site modification via mutatlons Fo DHPS, gene duplicatlans, or a plasmid with mutations in the TMP or SMX binding sites OVERVIEW OF ANTIBIOTICS •B-lactams: inhibut cell wall synthesis; bactencidal >Denicillins, cephalosporuns. Sulfonamides: prevent growth.and replication; bacteriostatic Prontosu, sulfadiazıne, suifisoxazole Aminoglycosides: inhibit protein synthesis; bactenadal Sreptomycin, neomycin, kanamyan, paro momycin ·Tetracycine : inhibit protein synthesis; bactenostatic →Tetracycline, doxyaycline, limecycine, oxytetracycine • Chicramphenicol: innioits protein synthesis; bactenostatic • Macrolides: inhibit protein synthesis; bacterostatic Erythromyciny. clanthromycin, azuthromycin. • Glycopeptides: inhubit ceul wau synthesis; bactericidal → Vancomycin, teicoplanin Ansamycins: innibit RNA synthesis; bacteriadal → Geldanamy un, nfamycin, naphthonycin al • Quinolanes: interfere with DNA replication and transcrptom, m →uprofloxaciny levofloxacin, trovafloxacin Streptogramins: inhubut protein synthesis; bactena" •Oxazolidinenes: inhibit protein synthesis; bact →Linezolid, pOszolid, tedizolid, cycoserir functions; bactenadal ·Lupopeptides:disrupt muetple cell me. Daptomyin sUi fou

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