Notes:

2 new characters with unique playstyles
90+ new collectible items to help Isaac fight
18+ new trinkets to swap and strategize with
80+ new enemies to face one after another
16+ new bosses to kill or be killed by
4000+ new rooms to explore and survive
A new secret final chapter for Isaac to endure
Bigger and greater secrets than ever before
Several new or enhanced features for local cooperative play
A nearly full and original new soundtrack, evocative of classic isaac