Notes:

A high quality screencap of the episode "Brian the Closer" where Lois is shown with large breasts (via plastic surgery) in a cutaway gag. Context of the gag is Peter interfered with the surgery by telling the doctor to give Lois breasts so huge she can't even button her blouse all the way, even though Lois herself only asked for c-cups at most (as the closed captioning points out, conveniently enough).

Again, methinks some of the artists on Family Guy really love giving Lois huge breasts.