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Machine Code is a comic/panel-based meme that involves Doctor Will Magnus looking at a paper and reacting to whatever is on the paper in a way related to the image/text on the paper.
Most “Machine Code” jokes involve existing memes and in-jokes, though there is the occasional that is not meme-based.
Google insights shows it spikes in March 2007.
The ED article was written November 2006.
This Facepunch thread is from January 2007.
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