Roguelikes have been a popular genre of video games lately. For some reason, people are into the idea of endless striving and struggling. The Binding of Isaac was an early example from famed indie developer Edmund McMillen where you play as a little boy named Isaac whose only weapons are his tears. The game recently got a massive update that integrates fan content with entirely new mechanics and story elements. It's rekindled some interest in the decade-old game, but it's never fallen out of style, especially in meme culture.