Origin: The meme "666 Losers Street" originated from a YouTube Shorts video uploaded on January 23, 2023, by a user named ShiroRBX. The video depicts Anylize attempting to hack another user, Yuka (who is known as ShiroRBX on YouTube), using a method described as the HAR file technique. The video description shows that this act is largely a joke, with ShiroRBX stating, "this is probably half a joke," and aims to take action for many Roblox players.

The catchy phrase "666 Losers Street" has since been adopted across various social media platforms as a way to refer to the absurdity of certain internet interactions.

The original video garnered significant attention, with over 2 million views within the year. Related comments have trended on social media.