Watamote is about a socially awkward girl desperately trying to be popular/be the star of her own little anime thing. She's a shut in otaku, and the show is hilariously/depressingly cringe inducing.

Bojack Horseman is about a washed up, alcoholic actor who was famous for being the star of a 90s sitcom about a horse dad, but never really got a gig afterwards. The first season is about him and an author writing his biography, and goes off from there. It is hilariously/depressingly cringe inducing.

Basically they're pretty similar shows with different set ups based on the culture they were created around.

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