Derpy, Carrot, Lyra, Bon, Scratch, and Berry (and Doctor, it they can get away with it). Badda-bing badda-boom, spin-off Mane Cast already lined up! Focus on Luna instead of Celestia. Trixie and Gilda as recurring antagonists (Team-Rocket-style, not hijacked-by-Ganon-style). The bronies would eat it up like hotcakes. No, hotcakes that vaccinate you against cancer!