The Think Tank aren't flanderized versions of their human selves because of being removed from their bodies. They're exaggerated versions of themselves because spending 200 years separated from their bodies (in addition to rigorous chem use) has driven them buttfuck insane.

Furthermore, 'flanderized versions of themselves' is still a personality. House isn't saying the human mind wasn't stable away from its body, he's saying that all human identity was erased.

Did they really "retain personality" though, the big mt doctors are like flanderized versions of themselves even the couriers brain admits to not being "you" and yeah correct me if I'm wrong but all the robo-brains I remember are either logic driven killers with no memory of the past (Jezebel) or tropy exaggerations of their old self's (the think tank and vault 118)