Snake and Otacon: Probably the two most identifiable characters in the franchise.

Now that I think about Otacon's quote, I wonder if otakus back then reacted to Otacon the same way we did with Monsoon. My sides still haven't recovered from reentry burns after being sent into orbit by the "DNA of the soul".

That joke is never going to die.
Its immortality is tied to the everlasting Triforce.