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“That Post Gave Me Cancer” is an image macro series commonly used in response to nonsensical or insubstantial posts submitted by the original poster (OP) or other users in a given thread. This hyperbolic expression implies that the content in question was so far below one’s expectation that it infected the reader with “cancer”, a slang term that is typically used on 4chan to express one’s disgust towards a trend or a thread.
The use of the term “cancer” as a metaphor of poor quality content began on 4chan’s /b/ (random) board as early as November 2007, most notably through the popularization of the phrase “X is the cancer that is killing /b/”. Sometime in 2009, its derivative expression “that post gave me cancer” began appearing on the site through an image macro instance posted in a 60s Spider-man thread.
The screen capture, which shows the Marvel superhero lying on the sick bed at the hospital, was originally taken from an episode of the 1967 Spider-Man TV series titled “To Cage a Spider.”