My Little Pony: Friendship is Magic - the Ship has sailed

They might be very distant. Keyword, might.

And hey, this is the same series that thought it was okay to have two adult ponies fall for an underaged human, so………

Not thar, I disagree, but…
"(Possible) being fourth cousins twice removed means that one of them is a 5th great grandson/daughter and the other is a 3rd great grandson/daughter of their common ancestor and that’s a HUGE genealogical distance, they have an average of 0.1% genes in common so at DNA level they are the same as two strangers."
~Baluh the Red Comet