I know this is a highly opinionated thread, but-
As I was saying, this is just from what I've seen as a older user that is probably too old to use a meme website, but as someone that's been using the internet for twenty five years and has been a member of fandoms towards a couple geeky things for a while:
A long term trend I've noticed is that a lot of the media and stories internet culture are putting are getting concept wise diversified. Back when I first started using the internet stuff like anime or such was considered "super hardcore". Ten years ago stuff like furries or transgender pictures were considered "super hardcore". Five years ago monster girls and traps were considered super hardcore by internet standards.
I don't know what the new thing is going to be, but if you'd like to take a shot in the dark as to what is going to be the next internet phenomenon go ahead.
There's also a trend of how it's slowly seeping into mainstream culture.
Ten years ago we had movies about a werewolf and a vampire competing for a teenage girls affection.
There was a bunch of movies involving humans dating robots.
There was a couple of movies involving humans dating aliens.
There's been a couple of movies involving humans having romantic relationships with mythical creatures.
A couple years ago we had a movie about a zombie falling in love with a human.
I would not be surprised if we get a romcom in the next few years about like a fox woman or such and a hot guy or a movie about a fox guy and a hot woman.
I know I'm drastically oversimplifying, but those are the most notable examples to clearly point out what I mean.