And I don't necessarily mean "ruined" in a bad way either, I just mean a meme has managed to warp your perception of something.
After countless Loss Edits, it's gotten to where every damn time I see a comic in a 2×2 panel style I end up just outright expecting it to be a Loss Edit. I'm more surprised when it's NOT an edit.
Also Moon Man has made watching those old Mac Tonight commercials rather interesting to say the least. More so whenever a piece of pop culture references Mac Tonight like The Simpsons or Homestar Runner (Strong Bad dressed as Mac Tonight in one of the Halloween cartoons).