Instagram has become notorious for deleting meme accounts, notably in many flare-ups and waves. This possibly may be connected to "raids" on popular figures like Hillary Clinton and Alyssa from Nooted. The terms of service prohibit a lot of the content that major meme accounts post.

Many users already prepare for this by making a backup account. Many meme pages bear a ".v2" or ".v5" in their username, with the number after the v denoting how many times they have been deleted.