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Fistful Of Yen is a two-panel exploitable showing what certain fictional characters would do if offered a large sum of money, commonly resulting in sexual favors or other perverted stuff.
The meme traces its origin to the second episode of the second season of the popular anime K-On! (shown below, left), which first aired on April 13, 2010. In the episode, the group finds an old guitar. Their instructor tells them to pawn it, and it sells for ¥500,000 (roughly $6,500 USD). The group then starts wondering what they should do with their share when Ritsu, the drummer, waves ¥100,000 in front of Azusa, the rhythm guitarist. The image was capped and became viral on Japanese anime forums for a short while, eventually resulting in a second panel being added (shown below, right).
Various examples of the exploitable can be found on Russian blogs and websites, such as Joyreactor.cc, Lurkmore.to, and the Russian social media website vk. Other examples can be found on the My Little Pony image board Deripbooru, Memecenter, and on Tumblr under the same tag.