Origin

The meme Francis Hates X come from the popular game Left 4 Dead, a survival-horror/action shooter game developed by VALVe Software. In the game, players take the role of 1 of 4 survivors, fighting through hordes of infected humans attempting to reach a safe house or be rescued.

The survivors are Bill, a Vietnam war veteran; Zoey, an average college girl and fan of horror movies/novels; Louis, the assistant manager at an electronics store, and father of the Grabbin' Peelz meme; and Francis, your average tattooed biker.

The meme stems from the dialogue of the character Francis, who in the game has the habit of declaring he hates whatever situation the player currently encounters.

For Example:
(Opens safe room door and sees a large staircase)
Francis: I hate stairs.
or
Louis: We should head for the river!
Francis: I hate the water.

Francis' seemingly random hatred gives him the appearance of hating everything. This has spawned multiple images, and is also quite commonly referenced in dialogue.

Usage

The meme, to a degree, is an exploitable as it usually consists of Francis, usually with an irritated look on his face, Photoshopped into a picture with a caption saying "I hate (Whatever is in the picture with him)". it's usage is most common on forums, image boards, and other such sites. This is usually utilized in buzzkilling, posting a Francis picture in response to another post or just saying what he would say. E.G:

Poster A: OMG I just got my first car!!!1!
Poster B: I hate cars.

An occasional opposite to this is an image declaring Francis doesn't hate something. This usage is somewhat rarer. This may be attributed to the fact that in the game, the only thing Francis is actually quoted as liking, are vests.