Notes:

Translation (thanks to Danbooru ) + commentary
Bros, remember, you can smoke, booze, or fight if you want, I can help you out if you're in trouble. But if any one of you has anything to do with THIS, then sorry, I (will pretend that I) don't know you… (This meme is about the Chinese gamers taking a jab at Overwatch being an addictive game to play, as if they're doing drugs. The template is basically used for anything they deem catchy; eg. Ikenai Borderline from Macross Delta.)