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Cyanide and Happiness is a webcomic series hosted on Explosm.net, written and illustrated by Kris Wilson, Rob DenBleyker, Matt Melvin and Dave McElfatrick.
According to Wikipedia, Kris Wilson began drawing comics by hand at the age of 16 when he was staying home while suffering from an illness. After he began making comics on the computer, he initially uploaded them to his personal website Comicazi. On December 9th, 2004, the site Explosm was created by Matt Melvin, Rob DenBleyker and Dave McElfatrick, who asked Wilson to share his comics on their site. The name of the series was inspired by a comic in which a character proclaims that his cotton candy is made out of “Cyanide & Happyness [sic].”
According to Wikipedia, the site received over a million daily vistors in November of 2006. As of May 3rd, 2012, Explosm holds an Alexa rank of 2,974, a Compete rank of 13,583 and a Quantcast rank of 15,448.
Explosm admins have occasionally allowed readers to submit content to be featured on the site, which included flash movies by the Ultimate Showdown Ultimate Destiny animator Shawn Vulliez. The site also contains flash animation movies, humor articles, a web forum and a merchandise store. The Explosm team have created their own flash animation videos as well, which have been uploaded to the video sharing website YouTube  and the flash animation site Newgrounds .
On January 19th, 2010, a collection of Cyanide and Happiness comics was published in a self-titled book. On October 5th, 2010, a second collection of comics was published in a book titled Ice Cream & Sadness. On October 28th, 2011, an official Cyanide and Happiness iPhone app was released on the iTunes App Store, which received a rating of four stars.