Twiscream is an exploitable screenshot from the recent Hasbro movie Equestria Girls, a spin-off of My Little Pony: Friendship is Magic. In the trailer there is a scene of Humanoid Twilight screaming, and it soon became an exploitable image on the brony site, Derpibooru.

Many photoshopped images with different captions referencing scenes of a character from different movies, shows, and books screaming dialogue or just doing incoherent nonsense.