Doomguy and Isabelle - I mean, Sakurai wouldn't...would he?

ninja woman with boobies; BAD

guy who eviscerates demons in such violent and gory ways it makes mortal kombat and happy tree friends look like a preschool kids show: GOOD

I could see them giving him a moveset that only has him using his pistol, rocket launcher, gauss cannon, plasma rifle, grenades, and his glory kill (As a grab).

if snake can only be restricted to explosives then i think doomguy can work with a some what limited arsenal.