I know Tosh.0 is a very popular show. It's not radio, it's television, and it's been on the air for a long time now.
From what I'm gathering, he knows the Internet as well as anyone, but he presents it to those who know the Internet as far as email, Facebook, and YouTube.
I think it could "blow up" or "blow over," leaning towards "blowing over." Your main audience for Tosh.0 aren't soccer moms. They probably actually look a lot like us: young, white adults. So they might say bronies are freaks, but…we are sorta weird in the first place. I don't think they'll begin to take to the streets or anything.
On the other hand, Tosh.0 is popular enough to have fans outside of their target demographic. And instead of talking about cloppers on a radio show, Daniel Tosh showed Fluttershy bits on television and said where it came from (i.e., reddit's "clopclop.")
It could go in either way, but I don't think that bronies are going to be targeted in any meaningful way. It's not illegal for us to watch My Little Pony. We're technically good.
The worst thing that could happen is that Rule 34 (of any show for children) is cracked down on, because a few politicians' children or wives got proper wind of it. There's enough Apple Bloom R34 out there, and I don't think anyone can say that she is "of age."
I also think that most mainstream people would laugh in your face if you said "But they're not real people. They're cartoon horses!" as an legitimate argument. I think we all know that US legislation gets made for bad reasons all of the time for matters that are more important than a few people being able to enjoy odd porn.
Futhermore, if it gets really out of hand, then Hasbro might try to cut ties with the brony community. They'd want FiM to stay on the air. It's making a ton of money for them. But they may cut out all fan nods or clearances of voice actors/actresses to things like cons and stuff. (Remember that voice actors have to have permission to go to conventions on behalf of the show.) Might have an effect on SFW fan art. Who knows.
I don't really think it'll be all that bad, but I'm really interested in seeing where this goes.
In other news, Equestria Daily decided to take down its post on Tosh's shoutout.
Interesting.