And note I'm talking like legit obscure stuff, not things that have a cult following.
One TV show I remembered existing recently is "Game Over." It was a CG animated series on UPN (back before Warner Bros. bought the channel and merged with with The WB to form "The CW") that lasted only a very small amount of episodes because ratings were just that bad (even so, I recall it getting a limited DVD release, probably in a failed attempt to recoup production costs). The premise is actually rather similar to Wreck-It-Ralph as it's about video game characters who live together in their own interconnected world.
Unlike Wreck-It-Ralph, Game Over was more of a Simpsons styled animated sitcom. The mom I recall being sort of a cross parody of Lara Croft and some fighting game characters, the dad a driver in a racing game, and while I remember pretty much nothing about the son character, I remember the daughter character was actually supposed to be part of a game that was a spoof of Dead or Alive Xtreme, only she hated the idea of wearing skimpy clothing constantly. The fact they actually spoofed DoA Xtreme of all things was interesting to me, and of course this came with things like jiggle physics and lots of boob and butt jokes.
To be honest, at the time when the show was brand new, I heard out it via the TV Guide and thought it sounded interesting, but my UPN only aired the first two episodes and nothing else, replacing the rest with reruns of Star Trek. As I said, the ratings were just that bad. Plus it's been so long since watching it I get the feeling my opinion on the show would probably really differ today, especially in light of things like Wreck-It-Ralph.