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Dora in a Coma refers to an image of the character Dora from Dora the Explorer seemingly hooked up to life support in a hospital bed. The image spread on Twitter as a reaction image for when a specific situation overwhelms the poster.
The image comes from the online flash game Dora Laparoscopic Appendectomy, a game in which the player performs an appendectomy on Dora. The game was posted September 1st, 2015 to Y8 games. On January 20th, 2018, Twitter user @ShayBayBay18 uploaded the image with a joke about a Frank Ocean song, gaining 48,000 retweets and 118,000 likes (shown below).
As the tweet with the image got popular, it stoked Twitter users' curiosity as to where the image came from. One rumor circulating was that it came from an episode of Dora the Explorer in which Dora gets Ebola (shown below, right). This theory is false, as no such episode exists. Twitter user @ginxie18 wrote a humorous backstory to the image in a tweet thread. The first tweet in the thread gained 80 retweets (shown below, right).