Uhh, have you seen the meme before? A lot of examples in the gallery aren't actually trying to say things literally about trans stuff. It's more just going deeper "down the rabbit hole". Many more people have played/ are aware of Super Mario, Sonic, and Kirby. A Hat in Time by comparison is more obscure, and Celeste moreso. While Celeste does perhaps benifit from giving the meme a potential double entendre, even without that it still works as well as the other examples.