Cruisin' On Down Main Street is a meme based on the theme song of the hit children's series The Magic School Bus.

Origin

The meme first appeared on Vine sometime in 2016, though the exact original clip or creator is unknown. The meme usually starts off with footage of the intro and things go about normally. However, when Arnold groans, it would cut to footage of a bus of some kind getting destroyed as the theme song becomes loud and distorted.

Spread

As of 2017, the meme has received multiple remakes and reworkngs. It has spread to multiple sites such as YouTube and Twitter.
One version circulating features the heads of Arnold and Phoeboe placed on the heads of a duo getting a bit too excited at a club.