About

Stewie "Pumpkin Pie" and He Took His Niece Who Had Cancer To See Santa refer to a series of Family Guy video edit memes that humorously splice "Top 10" and "Top 5" Family Guy Moments and repeat two recurring lines: Stewie Griffin saying, "Pumpkin pie," because he forgot his line in the intro song and Glenn Quagmire being a "good guy" because he took his niece, who has cancer, to see a mall Santa Claus. Another popular quote in the edits was The Cow That Enjoyed Being Milked. The brainrot memes, which remixed the AI voiceovers from YouTube creators Screen Addicts and Screen Empire, surfaced on TikTok in late 2025.

Origin

He Took His Niece Who Had Cancer To See Santa

On November 21st, 2025, TikToker^[3] @crushacow shared a video edit meme that used a Family Guy Moments compilation called "5 Times Quagmire Was Actually A Good Guy" from YouTuber^[1] Screen Empire, originally shared on August 21st, 2024.

In the video, @crushacow repeated a soundbite of the male voiceover saying, "He took his niece who had cancer to see Santa," concerning a scene in season 9, episode 7 of Family Guy titled, "Road to the North Pole."^[4] Over 10 days, the video received over 174,400 likes.

Stewie "Pumpkin Pie"

On November 27th, 2025, TikToker^[8] @xxyuriyaoixx shared a similar video edit meme that spliced a Family Guy Moments compilation called "5 More of The Funniest Family Guy Intro Moments" by YouTuber^[2] Screen Addicts, originally shared on September 5th, 2023.

The edit repeated Stewie Griffin forgetting his lines and saying, "Pumpkin pie" in the intro song, from season 14, episode 15, titled, "A Lot Going on Upstairs."^[9] Over four days, the video received over 103,500 likes.

Spread

On November 22nd, 2025, Twitter / X ^[5] user @WATER19996 reposted @crushacow's video, gaining over 8,300 likes in nine days.

The video was also reposted by Instagram ^[6] user @squidysgalaxy on that same day, gaining over 2,700 likes over the same timeframe.

Also on November 22nd, TikToker^[7] @crushacow shared a new iteration of the He Took His Niece Who Had Cancer To See Santa meme, gaining over 11,400 likes in nine days.

On November 30th, 2025, TikToker^[10] @splitpeanis shared a video edit meme that used the Stewie "Pumpkin Pie," He Took His Niece Who Had Cancer To See Santa clips and The Cow That Enjoyed Being Milked clips, as well as the Eat Grilled Chicken clip. In a day, the video received over 16,300 likes.

Also on November 30th, X^[11] user @NieceWithCancer, a gimmick account dedicated to the He Took His Niece Who Had Cancer To See Santa meme, posted a photo of the scene on a computer screen, captioned, "I've reached the episode…" In a day, the tweet garnered over 15,000 likes.

Various Examples

Search Interest

External References